Looking to up your side veggie game this Thanksgiving? Well, look no further. This Mediterranean-inspired roasted Brussels sprouts recipe is simple, quick, and oh so yummy — it’ll be gone in seconds!

These Brussels sprouts are more than your typical roasted sprouts. These oven roasted veggies feature a deliciously crisp exterior, and are generously seasoned with flavors inspired by Mediterranean (specifically Greek) cuisine. Fun fact: the spice choices were pulled directly from the marinade I use for making chicken gyros!

To put this dish over the top, I’ve included a trustworthy recipe (I’ve used it for years!) for a creamy and flavor-packed tzatziki sauce. It’s bright, garlicky, and a perfect pair for veggies, pita bread, gyros, and more! The tzatziki sauce is best made ahead of time and stored in the fridge hours before being served.

Mediterranean-Inspired Roasted Brussels Sprouts

  • Prep Time:10 mins
  • Cook Time:20 mins
  • Total Time:30 mins
  • Servings:3
  • Easy


  • 1 pound Brussels sprouts
  • 3 cloves garlic minced
  • 3 tablespoons extra virgin olive oil
  • 1/2 lemon
  • 1 tablespoon oregano
  • 1 teaspoon cumin
  • 1 teaspoon paprika
  • 1/2 teaspoon coriander
  • 1/8 teaspoon cayenne pepper
  • 1 cup Greek yogurt
  • 1/2 cucumber
  • 4 cloves garlic minced
  • 1 teaspoon white vinegar
  • 1 tablespoon extra virgin olive oil
  • Salt
Joseph Labrador.
  • Step 1

    Preheat the oven to 425° Fahrenheit

  • Step 2

    Prepare the Brussels sprouts by cutting off excess stems and cutting some sprouts in half. Each piece should be roughly the same size.

  • Step 3

    In a bowl, combine the minced garlic, juice of ½ lemon, 1 tablespoon oregano, 1 teaspoon cumin, 1 teaspoon paprika, ½ teaspoon coriander, and a pinch (or 1/8 teaspoon) of cayenne pepper. Add in a generous pinch of salt and pepper to taste.

  • Step 4

    Whisk the mixture until well combined.

  • Step 5

    Toss the Brussels sprouts into the bowl until they are evenly coated in the mixture.

  • Step 6

    Place the Brussels sprouts on an unlined baking sheet. Make sure the sprouts are spread out and not crowded together.

  • Step 7

    Bake the Brussels sprouts in the oven for 20 minutes or until they have browned and become crispy on the outside.

  • Step 8

    While the Brussels sprouts are in the oven, make the tzatziki sauce. Blend ½ cucumber using a blender or food processor. Once blended, mix the cucumber with 1 cup Greek yogurt, minced garlic, 1 teaspoon white vinegar, and 1 tablespoon extra virgin olive oil. The tzatziki sauce can be made ahead of time.

  • Step 9

    Once the Brussels sprouts are cooked, serve immediately and enjoy with tzatziki sauce.